HCID 178418361, compound → HCID 178511562, compound

HRID 1530820Notes

Reaction equation

HRID 1530820 reaction equation
[H][H].C([NH:10][C@H:11]1[CH2:16][CH2:15][C@@H:14]([CH:17]([OH:22])[C:18]([F:21])([F:20])[F:19])[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[OH:22][CH:17]([C@@H:14]1[CH2:15][CH2:16][C@H:11]([NH2:10])[CH2:12][CH2:13]1)[C:18]([F:19])([F:20])[F:21]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178520974HCID 178520974, compound

Product 1

HCID 178511562HCID 178511562, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

At 50° C. and a hydrogen pressure of 30 bar, 33.6 g of cis-1-benzylamino-4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexane were hydrogenated in the presence of 2 g of palladium (10% on carbon) in 250 ml of methanol. The catalyst was filtered off and the mixture was concentrated to give the title product as a colourless oil.

Workup

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-724ea9b0a7d94277b3c8bdb0f6195cd7
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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