HCID 21252697, compound → HCID 21252688, compound

HRID 1530822Notes

Reaction equation

HRID 1530822 reaction equation
[H][H].C([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([O:23][CH3:24])([CH3:22])[C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH3:24][O:23][C:17]([C:14]1[CH:13]=[CH:12][C:11]([OH:10])=[CH:16][CH:15]=1)([CH3:22])[C:18]([F:19])([F:20])[F:21]

Participants

5

Reactant 2

HCID 21252697HCID 21252697, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21252688HCID 21252688, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

At 50° C. and a hydrogen pressure of 5 bar, 24.5 g of 1-benzyloxy-4-(1-methoxy-1-methyl-2,2,2-trifluoroethyl)benzene in 150 ml of glacial acetic acid were hydrogenated in the presence of 1.4 g of palladium (10% on carbon). The catalyst was filtered off and the mixture was concentrated to give the title product as a colourless oil.

Workup

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-324f39ca74fc4b1da7fe370fc4a35fd5
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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