HCID 21253084, compound → HCID 21253068, compound

HRID 1530851Notes

Reaction equation

HRID 1530851 reaction equation
[ClH:1].[Br:2][C:3]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([NH2:16])=[C:9]2[C:4]=1[CH2:5][CH2:6][NH:7][CH2:8]2>CO.[Pd]>[ClH:1].[BrH:2].[CH2:8]1[C:9]2[C:4](=[CH:3][CH:12]=[C:11]([NH2:13])[C:10]=2[NH2:16])[CH2:5][CH2:6][NH:7]1

Participants

4

Reactant 1

HCID 21253084HCID 21253084, compound

Product 1

HCID 21253068HCID 21253068, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product from Example 5 (7 g) in 250 mL of methanol was treated with 20% Pd/C (1 g) and shaken on a Parr apparatus under a hydrogen atmosphere (50 psi) for 16 h at ambient temperature. The catalyst was removed by filtration and the filtrate evaporated to give the product as a purple solid (6.3 g, 99% yield) that was used immediately without further purification.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-3ecbf170590c47aab876e1418107ae61
Source dataset
uspto-grants-2001_03
Patent number
US06197771B1

Reaction notes

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