N-Hydroxysuccinimide → HCID 69746761, compound

Participants

Reaction Steps

Dicyclcohexylcarbodiimide (24.1 g, 117 mmol) dissolved in THF is added to a solution of oleic acid (30 g, 106.2 mmol) in 150 ml of THF at 0° C. After 20 minutes, N-hydroxysuccinimide (13.5 g, 117 mmol) is added to the mixture. The mixture is slowly warmed to room temperature. After 18 hours at room temperature, cooling to 0° C. is effected, and the precipitate is sucked off. The filtrate is concentrated and purified on a silica gel column using ethyl acetate/heptene (1:3). Yield: 83% of a colorless wax.

Provenance & Evidence