Sodium Hydroxide → HCID 15872431, compound

Participants

Reaction Steps

12 (1.76 mmol) is dissolved in 20 ml of dichloromethane, and 50 ml of a 1% methanolic NaOH solution is added. This is concentrated after 20 hours at room temperature, and the residue is acidified with 1N HCl. The mixture is extracted with ethyl acetate. The combined organic phases are washed with 50 ml of H2O and dried over MGSO4, filtrated and concentrated. The residue is treated with methanol. Yield: 82% of colorless crystals.

Provenance & Evidence