Sodium borohydride → HCID 9860886, compound

HRID 1530881Notes

Reaction equation

HRID 1530881 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[C:13]3[NH:12][CH:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH2:10][C:9](=[O:20])[C:8]=3[CH:7]=[CH:6][N:5]2[C:21]=1[CH3:22].[BH4-].[Na+]>CO>[OH:20][CH:9]1[C:8]2[CH:7]=[CH:6][N:5]3[C:21]([CH3:22])=[C:2]([CH3:1])[N:3]=[C:4]3[C:13]=2[NH:12][CH:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22341780HCID 22341780, compound

Product 1

HCID 9860886HCID 9860886, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 1 g of 2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridin-7-one in 15 ml of methanol is treated at room temperature with 450 mg of sodium borohydride in small portions. The resulting yellowish solution is stirred for 2 h and then diluted with ice water. The precipitate which is deposited is filtered off with suction and washed with a little cold 2-propanol. 800 mg of the title compound of melting point 210-12° C. are obtained.

Workup

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. washwashed with a little cold 2-propanol

Sources & evidence

ORD record
ord-c1af1bcf0b85434f85c0ab4767e84e7a
Source dataset
uspto-grants-2001_03
Patent number
US06197783B1

Reaction notes

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