HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde → 3-Chloro-4-[(4-{[(8-fluoro-2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde | HCID 57423109 | — |
| Reactant | 4-[(4-Amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one | HCID 57707475 | — |
| Product | 3-Chloro-4-[(4-{[(8-fluoro-2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Hydrochloride | HCID 68684979 | 56% |
Reaction Steps
The free base of the title compound was prepared from 4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one (32 mg) and 8-fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde (18.2 mg) according to the general method of Example 2(h) in 56% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732461B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e041b4d3eddd4e24b6e74471c998eb0a |
| Source note | uspto-grants-2010_06 |