HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-3-acetyl-1,3-thiazolidine-4-carboxylic acid → N-Acetyl-D-thioproline 4-(trifluoromethyl)-DL-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-3-acetyl-1,3-thiazolidine-4-carboxylic acid | HCID 749158 | — |
| Reactant | Methyl 2-amino-3-(4-(trifluoromethyl)phenyl)propanoate | HCID 21253330 | — |
| Product | N-Acetyl-D-thioproline 4-(trifluoromethyl)-DL-phenylalanine | HCID 131722413 | — |
Reaction Steps
from 4-(trifluoromethyl)-DL-phenylalanine methyl ester and N-acetyl-D-thioproline δH (DMSO-d6) 8.56-8.12 (1 H, m,NH), 7.68-7.55 (2 H, m, ArH), 7.51-7.37 (2 H, m, ArH),4.85-4.15 (4 H, m, NCH2S and 2×α-CH), 3.40-2.65 (4 H, m,SCH2CH and CH2Ar),2.06 (s) and 2.04 (s) and 1.80(s) and 1.71 (s); together (3 H, COCH3); m/z (ESI, 60 V), 391 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197794B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-cfacfe01dd6c4d95a66294b362a6579d |
| Source note | uspto-grants-2001_03 |