Sodium Hydroxide → HCID 15886919, compound

HRID 1530953Notes

Reaction equation

HRID 1530953 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:24]4=[C:25]([C:27](=[O:37])[C:28]([CH2:30][C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)=[CH:29][N:23]4[C:22]4[CH:21]=[CH:20][C:19]([Br:38])=[CH:18][C:17]3=4)[CH:26]=2)[CH:9]=[N:10][CH:11]=1)(=O)C.[OH-].[Na+]>CO.O>[Br:38][C:19]1[CH:20]=[CH:21][C:22]2[N:23]3[CH:29]=[C:28]([CH2:30][C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)[C:27](=[O:37])[C:25]4[CH:26]=[C:14]([O:13][CH2:12][C:8]5[CH:9]=[N:10][CH:11]=[C:6]([CH2:5][OH:4])[CH:7]=5)[CH:15]=[C:16]([C:17]=2[CH:18]=1)[C:24]3=4

Participants

5

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 15886918HCID 15886918, compound

Product 1

HCID 15886919HCID 15886919, compoundYield 97.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2- (5-acetoxymethyl-3-pyridylmethyloxy)-10-bromo-5-(3-pyridylmethyl)-4H-pyrido [3,2,1-jk]carbazole-4-one (200 mg) obtained in Example 24 was suspended in methanol (10 ml), and to the suspension was added an aqueous solution of sodium hydroxide (a solution prepared by dissolving 85 mg of sodium hydroxide in 0.8 ml of water), and the mixture was stirred at room temperature for 1 hour. The crystals precipitated were washed with methanol and ether in succession, and recovered by filtration to obtain the title compound (180 mg, 97%).

Workup

  1. customprepared
  2. customThe crystals precipitated
  3. washwere washed with methanol and ether in succession
  4. filtrationrecovered by filtration

Sources & evidence

ORD record
ord-6e34e514ef614d5c8c90ecc7af22581c
Source dataset
uspto-grants-2001_03
Patent number
US06197768B1

Reaction notes

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