Ethanol → HCID 19364888, compound

HRID 1530980Notes

Reaction equation

HRID 1530980 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:18]=[C:17]([CH2:19][N:20]4[CH:24]=[N:23][CH:22]=[N:21]4)[C:16](=[O:25])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[C:26](OC(=O)C)(=[O:28])[CH3:27].C(O)C>N1C=CC=CC=1>[C:26]([O:15][C:10]1[CH:11]=[C:12]2[C:7]3=[C:8]([C:16](=[O:25])[C:17]([CH2:19][N:20]4[CH:24]=[N:23][CH:22]=[N:21]4)=[CH:18][N:6]3[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:14][C:13]2=3)[CH:9]=1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 702EthanolHCID 7918Acetic AnhydrideHCID 19364920HCID 19364920, compound

Product 1

HCID 19364888HCID 19364888, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10-bromo-2-hydroxy-5-(1H-1,2,4-triazole-1-ylmethyl)-4H-pyrido [3,2,1-jk]carbazole-4-one (30 mg) obtained in Example 96 was suspended in pyridine (0.8 ml), and acetic anhydride (0.021 ml) was added, and the mixture was stirred at room temperature for 3 hours. After adding dropwise a small amount of ethanol to the reaction mixture, the solvent was evaporated under reduced pressure. The residue was washed with ethanol and ether in succession to obtain the title compound (24 mg, 72%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethanol and ether in succession

Sources & evidence

ORD record
ord-fbee3d718a524746b91a8e401f9c7e63
Source dataset
uspto-grants-2001_03
Patent number
US06197768B1

Reaction notes

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