Sodium Hydroxide → HCID 19364865, compound

HRID 1530987Notes

Reaction equation

HRID 1530987 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:24]4=[C:25]([C:27](=[O:37])[C:28]([CH2:30][C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)=[CH:29][N:23]4[C:22]4[CH:21]=[C:20]([Br:38])[CH:19]=[CH:18][C:17]3=4)[CH:26]=2)[CH:9]=[N:10][CH:11]=1)(=O)C.[OH-].[Na+]>CO.O>[Br:38][C:20]1[CH:19]=[CH:18][C:17]2[C:16]3[C:24]4=[C:25]([C:27](=[O:37])[C:28]([CH2:30][C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)=[CH:29][N:23]4[C:22]=2[CH:21]=1)[CH:26]=[C:14]([O:13][CH2:12][C:8]1[CH:9]=[N:10][CH:11]=[C:6]([CH2:5][OH:4])[CH:7]=1)[CH:15]=3

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19364914HCID 19364914, compound

Product 1

HCID 19364865HCID 19364865, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2-(5-acetoxymethyl-3-pyridylmethyloxy)-9-bromo-5-(3-pyridylmethyl)-4H-pyrido [3,2,1-jk]carbazole-4-one (200 mg) produced in Example 106 was suspended in methanol (10 ml), and to the suspension was added a solution of sodium hydroxide (85 mg) in water (0.8 ml). The mixture was stirred at room temperature for 10 minutes, and the crystals precipitated were recovered by filtration, and washed with methanol and ether in succession to obtain the title compound (170 mg, 92%).

Workup

  1. customthe crystals precipitated
  2. filtrationwere recovered by filtration
  3. washwashed with methanol and ether in succession

Sources & evidence

ORD record
ord-e5b9cd70abad4940add9eef11c28233b
Source dataset
uspto-grants-2001_03
Patent number
US06197768B1

Reaction notes

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