Butyryl chloride → HCID 19364933, compound

HRID 1531011Notes

Reaction equation

HRID 1531011 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:18]=[C:17]([CH2:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16](=[O:26])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[CH3:27][CH2:28][CH2:29][C:30](Cl)=[O:31]>N1C=CC=CC=1>[C:30]([O:15][C:10]1[CH:11]=[C:12]2[C:7]3=[C:8]([C:16](=[O:26])[C:17]([CH2:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)=[CH:18][N:6]3[C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:14][C:13]2=3)[CH:9]=1)(=[O:31])[CH2:29][CH2:28][CH3:27]

Participants

4

Reactant 2

HCID 8855Butyryl chlorideHCID 19364896HCID 19364896, compound

Product 1

HCID 19364933HCID 19364933, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10-fluoro-2-hydroxy-5-(3-pyridylmethyl)-4H-pyrido [3,2,1-jk]carbazole-4-one (150 mg) produced in Example 236 was suspended in pyridine (12 ml), and n-butyryl chloride (74 gl) was added dropwise to the suspension in an ice bath. After stirring for 50 minutes, the solvent was evaporated under reduced pressure. The residue was washed with ether to obtain the title compound (126 mg, 70%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ether

Sources & evidence

ORD record
ord-2d61edecd6e846d9a2ed94e46e529ca9
Source dataset
uspto-grants-2001_03
Patent number
US06197768B1

Reaction notes

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