4-(2-Piperidin-1-yl-ethoxy)benzyl chloride → 2-(Octane-1-sulfonyl) 3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([S:7]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])(=[O:9])=[O:8])[CH3:6])[CH3:2].ClC[C:21]1[CH:35]=[CH:34][C:24]([O:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]([S:7]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])(=[O:9])=[O:8])[CH2:6][C:21]1[CH:22]=[CH:23][C:24]([O:25][CH2:26][CH2:27][N:28]2[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]2)=[CH:34][CH:35]=1)[CH3:2]Participants
3
Procedure
2-(Octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester was prepared according to the general method as outlined in example 9 . Starting from 2-(octane-1-sulfonyl)-propionic acid ethyl ester (5.0 g, 18 mmol) and 1-[2-(4-chloromethylphenoxy)-ethyl]-piperidine (5.6 g, 19.7 mmol); Yield 8.9 g (96%); amber oil, MS 495.
Sources & evidence
- ORD record
- ord-1e2ac200639142bf928412d0b0793b7b
- Source dataset
- uspto-grants-2001_03
- Patent number
- US06197791B1
Reaction notes
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