1-Bromo-2-butyne → HCID 18416709, compound

HRID 1531070Notes

Reaction equation

HRID 1531070 reaction equation
C([O:5][C:6](=[O:25])[CH:7]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)(C)(C)C.Br[CH2:27][C:28]#[C:29][CH3:30]>>[F:24][C:21]1[CH:22]=[CH:23][C:18]([S:15]([C:7]([CH2:8][C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)([CH2:27][C:28]#[C:29][CH3:30])[C:6]([OH:5])=[O:25])(=[O:16])=[O:17])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 54225501HCID 54225501, compound

Product 1

HCID 18416709HCID 18416709, compoundYield 100%

Procedure

The title compound was prepared according to the procedure as outlined in Example 70. Starting from 2-(4-fluoro-benzenesulfonyl)-3-pyridin-3-ylpropionic acid tert-butyl ester (1.83 g, 5.0 mmol) and 1-bromo-2-butyne (0.67 g, 5.0 mmol), 2.18 g of the product was isolated. Yield 100%; yellowish gum; MS: 419.2 (M+H)+.

Sources & evidence

ORD record
ord-bc3b29cc0d5449b09cea37b69883fdf7
Source dataset
uspto-grants-2001_03
Patent number
US06197791B1

Reaction notes

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