HCID 11038125, compound → HCID 10884843, compound

Participants

Reaction Steps

1-(4-Fluoro-benzyl)-4-(4-butoxy-benzenesulfony)-piperdine-4-carboxylic acid was prepared starting from 1-(4-Fluoro-benzyl)-4-(4-butoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (4.77 g, 10 mmol) dissolved in THF:methanol 3:1 and 10 N NaOH (10 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 3.5 g (79%); off white solid; mp 114° C.; MS: 450 (M+H)+.

Provenance & Evidence