HCID 10915970, compound → HCID 10959203, compound

HRID 1531113Notes

Reaction equation

HRID 1531113 reaction equation
C([O:3][C:4]([C:6]1([S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C>CO.[OH-].[Na+]>[CH3:12][N:9]1[CH2:8][CH2:7][C:6]([S:13]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:20][CH:21]=2)(=[O:15])=[O:14])([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 10915970HCID 10915970, compound

Product 1

HCID 10959203HCID 10959203, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1-Methyl-4-(4-butoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-methyl-4-(4-butoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (7.6 g, 20 mmol) dissolved in methanol (300 ml) and 10 N NaOH (35 ml). The resulting reaction mixture was worked up outlined in example 83. Yield 6.0 g (84%); white solid; mp 195° C.; MS: 356.4 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-33de89ba7f504a5da2afd2e15df15e17
Source dataset
uspto-grants-2001_03
Patent number
US06197791B1

Reaction notes

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