N-Benzylnormechlorethamine → 1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	N-Benzylnormechlorethamine	HCID 5928	—
Reactant	[4-(4-Chloro-phenoxy)-benzenesulfonyl]-acetic acid ethyl ester	HCID 11121795	—
Product	1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester	HCID 10973288	—

Reaction Steps

1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method outlined in example 83 starting from [4-(4-chloro-phenoxy)-benzenesulfonyl]-acetic acid ethyl ester (6 g, 16.9 mmol) and bis-(2-chloro-ethyl)-benzyl amine (6.44 g, 24 mmol). Yield 2.21 g (25%); yellow oil; MS: 513.9 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06197791B1
Source dataset	uspto-grants-2001_03
ORD ID	ord-f70d2d3502e0444f8cbf48ef37aef9e4
Source note	uspto-grants-2001_03