HRID1531265

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](N)C(=O)O)cc1.c1cscn1

HCID178427568

未命名化合物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)O)cc1

HCID178427608

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)CNC(=O)[C@@H](CCCNC(=N)NS(=O)(=O)c2ccc(C)cc2)NS(=O)(=O)Cc2ccccc2)C(=O)O)cc1.c1cscn1

HCID178427557

未命名化合物

收率 63%

PROCEDURE

实验过程

A 100 mg portion of the compound of Example 11 was coupled with 0.19 mmol of H-Arg(Tos)-thiazole (prepared following the procedure of Example 5) following the procedure as described in Example 6. RP-HPLC purification gave the title compound (110 mg, 63% yield). FAB-MS (M+H)+917.8

WORKUP

后处理

customprepared
customRP-HPLC purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5a1c1570ca145d58a2e6f34b2291423
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06197748B1
来源说明: uspto-grants-2001_03

反应 SMILES

[CH2:1]([S:8]([NH:11][C@@H:12]([C:30]([NH:32][CH2:33][C:34](O)=[O:35])=[O:31])[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:29])[NH:18][S:19]([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:21])=[O:20])(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:37][C@H:38]([C:56]([OH:58])=[O:57])[CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:55])[NH:44][S:45]([C:48]1[CH:54]=[CH:53][C:51]([CH3:52])=[CH:50][CH:49]=1)(=[O:47])=[O:46].[S:59]1[CH:63]=[CH:62][N:61]=[CH:60]1>>[CH2:1]([S:8]([NH:11][C@@H:12]([C:30]([NH:32][CH2:33][C:34]([NH:37][C@H:38]([C:56]([OH:58])=[O:57])[CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:55])[NH:44][S:45]([C:48]1[CH:54]=[CH:53][C:51]([CH3:52])=[CH:50][CH:49]=1)(=[O:47])=[O:46])=[O:35])=[O:31])[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:29])[NH:18][S:19]([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:20])=[O:21])(=[O:9])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[S:59]1[CH:63]=[CH:62][N:61]=[CH:60]1