(1S)-(+)-Camphor-10-sulphonic acid → (s)-5-Bromo-2,3-dihydro-1h-inden-2-amine

HRID 1531266Notes

Reaction equation

HRID 1531266 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([NH2:11])[CH2:5]2.[C@]12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][C@H:6]([NH2:11])[CH2:5]2

Participants

3

Reactant 2

HCID 218580(1S)-(+)-Camphor-10-sulphonic acidHCID 112987955-bromo-2,3-dihydro-1H-inden-2-amine

Product 1

HCID 46899973(s)-5-Bromo-2,3-dihydro-1h-inden-2-amine

Procedure

resolving 5-bromo-2-aminoindane with either (R) or (S)-10-camphorsulfonic acid to obtain either chiral (R)- or (S)-5-bromo-2-aminoindane;

Sources & evidence

ORD record
ord-a35e194ba6f3473081a786584d65037c
Source dataset
uspto-grants-2001_03
Patent number
US06197798B1

Reaction notes

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