HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid | HCID 55251 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride | HCID 11066000 | — |
Reaction Steps
To a solution of 4′-trifluoromethyl-2-biphenylcarboxylic acid (5.15 g, 19.35 mmol) in methylene chloride (100 mL) is added oxalyl chloride (5.06 mL, 58.04 mmol) followed by 2 drops of DMF. Addition of DMF results in vigorous gas evolution. After 1.5 h, the reaction mixture is concentrated under reduced pressure to give an oil which is used as is without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197798B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-4ae411326a594e88b2d00f8c07733403 |
| Source note | uspto-grants-2001_03 |