HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Bromo-5-nitrobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Bromo-5-nitrobenzoic acid | HCID 243025 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Bromo-5-nitrobenzoyl chloride | HCID 11471072 | — |
Reaction Steps
To a solution of 2-bromo-5-nitrobenzoic acid (1.00 g, 4.06 mmol) in methylene chloride (15 mL) is added oxalyl chloride (1.42 mL, 16.24 mmol) followed by 1 drop DMF. Addition of DMF results in vigorous gas evolution. After 1.5 h, the reaction mixture is concentrated under reduced pressure to give an oil which is used as is without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197798B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-c83b5af817fc41bdb8042d21c857dcde |
| Source note | uspto-grants-2001_03 |