Sodium Hydroxide → HCID 86756501, compound

HRID 1531317Notes

Reaction equation

HRID 1531317 reaction equation
[OH-].[Na+:2].[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12]3[C:13](=[O:43])[O:14][C:15]([OH:42])([C:34]4[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=4)[C:16]=3[CH2:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[C:20]([O:32][CH3:33])[CH:19]=3)[CH:9]=[CH:8][C:7]=12>CO>[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12](=[C:16]([CH2:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[C:20]([O:32][CH3:33])[CH:19]=3)[C:15]([C:34]3[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=3)=[O:42])[C:13]([O-:43])=[O:14])[CH:9]=[CH:8][C:7]=12.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 110608753-(2,1,3-Benzothiadiazol-5-yl)-4-(4-cyclopentyloxy-3,5-dimethoxy-benzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one

Product 1

HCID 86756501HCID 86756501, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Equimolar amounts of 0.1N NaOH are added to a suspension of 30 mg of 3-(2,1,3-benzothiadiazol-5-yl)-4-(4-cyclopentyloxy-3,5-dimethoxybenzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one in 1 ml of methanol and the mixture is stirred at room temperature. The solvent is removed, the residue is partitioned between water and diethyl ether, and the aqueous phase is then lyophilized. Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-(4-cyclopentyloxy-3,5-dimethoxybenzyl)-4-(4-methoxyphenyl)-4-oxo-2-butenoate is obtained.

Workup

  1. customThe solvent is removed
  2. customthe residue is partitioned between water and diethyl ether

Sources & evidence

ORD record
ord-bad04422945b498396a868e4fa66f9e2
Source dataset
uspto-grants-2001_03
Patent number
US06197800B1

Reaction notes

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