HRID1531317

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC3CCCC3)c(OC)c2)cc1

HCID11060875

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)C(Cc2cc(OC)c(OC3CCCC3)c(OC)c2)=C(C(=O)[O-])c2ccc3nsnc3c2)cc1.[Na+]

HCID86756501

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Equimolar amounts of 0.1N NaOH are added to a suspension of 30 mg of 3-(2,1,3-benzothiadiazol-5-yl)-4-(4-cyclopentyloxy-3,5-dimethoxybenzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one in 1 ml of methanol and the mixture is stirred at room temperature. The solvent is removed, the residue is partitioned between water and diethyl ether, and the aqueous phase is then lyophilized. Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-(4-cyclopentyloxy-3,5-dimethoxybenzyl)-4-(4-methoxyphenyl)-4-oxo-2-butenoate is obtained.

WORKUP

后处理

customThe solvent is removed
customthe residue is partitioned between water and diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bad04422945b498396a868e4fa66f9e2
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06197800B1
来源说明: uspto-grants-2001_03

反应 SMILES

[OH-].[Na+:2].[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12]3[C:13](=[O:43])[O:14][C:15]([OH:42])([C:34]4[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=4)[C:16]=3[CH2:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[C:20]([O:32][CH3:33])[CH:19]=3)[CH:9]=[CH:8][C:7]=12>CO>[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12](=[C:16]([CH2:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[C:20]([O:32][CH3:33])[CH:19]=3)[C:15]([C:34]3[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=3)=[O:42])[C:13]([O-:43])=[O:14])[CH:9]=[CH:8][C:7]=12.[Na+:2]