(4-Methoxyphenyl)boronic acid → HCID 70133754, compound

Participants

Reaction Steps

Methyl 2-{[4′-methoxy-(1,1′-biphenyl)-4-yl]-sulfonyl}-amino-5-(3-morpholino-phenyl)-pent-4-ynoate: The starting sulfonamide 5b (367 mg, 0.66 mmol) is converted to the title compound with 4-methoxyphenylboronic acid (151 mg. 1.14 mmol) as described. for compound 3b. The crude product is adsorbed onto silica and then eluted through a column of flash silica with Hexanes:EtOAc (4:1 to 1:1) to give a pale orange-yellow, foamy solid.

Provenance & Evidence