Sulfuric Acid → HCID 21253733, compound

Participants

Reaction Conditions

Reaction Steps

59.4 g (0.2 mol) of 5-(2′-aminophenyl)-3-[2-(2-hydroxyethylsulfonyl)ethyl]-1,2,4-oxadiazole were added at 10-15° C. to 100% strength sulfuric acid and stirred in at 40° C. for 1 h. 240 ml of 24% strength by weight oleum were then added at 40° C. a little at a time over 20 h. After heating at 60° C. for 8 h, the reaction solution was poured onto ice, the pH was adjusted to pH 4-5 with sodium bicarbonate, and the product was salted out with 500 g of potassium chloride to afford 95.3 g of 5-(2′-amino-5′-sulfophenyl)-3-[2-(2-hydroxyethylsulfonyl)ethyl]-1,2,4-oxadiazole.

Provenance & Evidence