1-Methoxy-2-propanol → HCID 21253722, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 132 g (0.55 mmol) of 3-chloromethyl-5-(3′-nitrophenyl)-1,2,4-oxadiazole (obtainable by reaction of 3-nitrobenzoyl chloride with chloroacetamide oxime), 39.0 ml (0.56 mol) of mercaptoethanol and 80 ml of triethylamine in 700 ml of 1-methoxy-2-propanol was heated to 100° C. for 4 h and, after cooling down, poured onto ice-water. The precipitated solid was filtered off with suction, washed with water and dried at 40° C. under reduced pressure. 142 g of the compound of the formula

Provenance & Evidence