反应详情

温度

110 °C

First, 8.05 g (113 mmol) of crotonaldehyde (2-butenal) and 9.17 g (54.9 mmol) of benzenesulfonyl cyanide were introduced to a 3-necked flask (50 ml volume) equipped with a thermometer, a magnetic stirrer, a Dean-Stark water type distilling receiver, and a condenser tube. Toluene (15 ml) as a solvent and butanol (1.5 ml) were added, and then 589 mg (5.55 mmol) of lithium perchlorate was added. Next, the mixture was heated under reflux for 15 hours while agitating at an internal temperature of 110° C. in a nitrogen atmosphere, and separating and removing water that was produced. After this solution was cooled to room temperature, the low-boiling components, such as solvent, etc., were removed under reduced pressure and the resulting concentrate was cooled in an ice bath to precipitate crystals. The crystals were filtered with a glass filter and washed with 10 ml of toluene that had been cooled to 5° C. or lower. Then the crystal were dried for 2 hours in vacuo to give 10.8 g of 2-benzenesulfonylpyridine having the following properties as colorless crystals (purity of 99%, yield of 89% based on benzenesulfonyl cyanide).

1. customequipped with a thermometer, a magnetic stirrer
2. distillationa Dean-Stark water type distilling receiver, and a condenser tube
3. additionToluene (15 ml) as a solvent and butanol (1.5 ml) were added
4. temperatureNext, the mixture was heated
5. temperatureunder reflux for 15 hours
6. customseparating
7. customremoving water that
8. customwas produced
9. temperatureAfter this solution was cooled to room temperature
10. customthe low-boiling components, such as solvent, etc., were removed under reduced pressure
11. concentrationthe resulting concentrate
12. temperaturewas cooled in an ice bath
13. customto precipitate crystals
14. filtrationThe crystals were filtered with a glass
15. filtrationfilter
16. washwashed with 10 ml of toluene that
17. temperaturehad been cooled to 5° C.
18. customThen the crystal were dried for 2 hours in vacuo