Ethanol → 4-(Diethylamino)-2-hydroxybenzaldehyde
Reaction equation
C1(C)C=CC(S([O-])(=O)=[O:8])=CC=1.[CH2:12]([C:14]1S[C:16]2[CH:24]=[CH:23][CH:22]=[CH:21][C:17]=2[N+:18]=1[CH2:19][CH3:20])C.[CH2:25]([OH:27])C>>[CH2:14]([N:18]([CH2:19][CH3:20])[C:17]1[CH:21]=[C:22]([OH:8])[C:23](=[CH:24][CH:16]=1)[CH:25]=[O:27])[CH3:12]Participants
3
Procedure
In 25 ml of ethanol, 1.82 g of the compound obtained in (1) and 1.06 g of 4-diethylaminosalicylaldehyde were dissolved, followed by heating to 100° C. To the resulting solution, 0.7 ml of piperidine was added and the mixture was heated under reflux for 2 hours. Then, the solution was ice-cooled. The colorless crystals so precipitated were collected by filtration, washed with ethanol and dried under vacuum for 2 days, whereby 0.83 g of the decolorizable compound I-1 was obtained.
Sources & evidence
- ORD record
- ord-983bd9a9833f412291e1e133aa4bd068
- Source dataset
- uspto-grants-2001_03
- Patent number
- US06197968B1
Reaction notes
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