Triethoxymethylsilane → (+)-Lactose

Participants

Reaction Steps

100 ml of methyltriethoxysilane are solubilized in a mixture of 80 g of water and 350 g of absolute ethanol. 1.1 kg of lactose monohydrate is then added to the solution (partially soluble), and the whole mixture is maintained under stirring at room temperature for 17 hours. The solvents are then progressively eliminated by distillation under reduced pressure (2000-2600 Pa) and moderate heat. Finally 1.12 Kg of a white pulverulent solid is obtained, which may be further transformed, by dissolution in water or in vivo, into a biologically active silanol with the same properties as the silanols from the prior art.

Provenance & Evidence