HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2,4,6-Trihydroxymethyl-s-triazine | HCID 22323664 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine | HCID 22323694 | — |
Reaction Steps
2,4,6-Trihydroxymethyl-s-triazine (1 eq.) is dissolved in an excess of pyridine. p-Toluenesulfonylchloride (0.9 eq.) in CH2Cl2 is added and the reaction mixture is stirred overnight. The solvent volume is reduced to a slurry to which water and dichloromethane are added and the resulting mixture is extracted with CH2Cl2. The combined CH2Cl2 layers are dried (MgSO4) and concentrated to an oil. The oil is purified by silica gel flash column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197965B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-1ab9092c59964ffaa8884d24287c0084 |
| Source note | uspto-grants-2001_03 |