HRID1531513

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21893726

Hydrochloride methanol

CH5ClO

结构：COc1ccccc1COCCCOc1ccc([C@H]2CCN(C(=O)OC(C)(C)C)C[C@@H]2OCc2ccc3c(c2)N(CCNS(C)(=O)=O)CCC3)cc1

HCID69489460

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1COCCCOc1ccc([C@H]2CCNC[C@@H]2OCc2ccc3c(c2)N(CCNS(C)(=O)=O)CCC3)cc1

HCID57123770

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 4(b), the (3R,4R)-3-[1-(2-methanesulfonylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester was deprotected with HCl/methanol to yield the (3R,4R)-3-[1-(2-methanesulfonylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine as a light yellow oil; MS: 638 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-962e66642e64485d92056962a2a8920f
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06197959B1
来源说明: uspto-grants-2001_03

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[O:32][CH3:33])=[CH:16][CH:15]=2)[C@@H:10]([O:34][CH2:35][C:36]2[CH:45]=[C:44]3[C:39]([CH2:40][CH2:41][CH2:42][N:43]3[CH2:46][CH2:47][NH:48][S:49]([CH3:52])(=[O:51])=[O:50])=[CH:38][CH:37]=2)[CH2:9]1)=O)(C)(C)C.Cl.CO>>[CH3:52][S:49]([NH:48][CH2:47][CH2:46][N:43]1[C:44]2[C:39](=[CH:38][CH:37]=[C:36]([CH2:35][O:34][C@@H:10]3[C@@H:11]([C:14]4[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=5[O:32][CH3:33])=[CH:18][CH:19]=4)[CH2:12][CH2:13][NH:8][CH2:9]3)[CH:45]=2)[CH2:40][CH2:41][CH2:42]1)(=[O:50])=[O:51]