Hydrochloride methanol → HCID 57249467, compound

HRID 1531525Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][CH:26]3[CH2:28][CH2:27]3)=[CH:16][CH:15]=2)[C@@H:10]([O:29][CH2:30][C:31]2[CH:40]=[C:39]3[C:34]([CH2:35][CH2:36][CH2:37][N:38]3[CH2:41][CH2:42][CH2:43][O:44][CH3:45])=[CH:33][CH:32]=2)[CH2:9]1)=O)(C)(C)C.Cl.CO>>[CH:26]1([CH2:25][O:24][CH2:23][CH2:22][CH2:21][O:20][C:17]2[CH:16]=[CH:15][C:14]([C@H:11]3[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]3[O:29][CH2:30][C:31]3[CH:40]=[C:39]4[C:34]([CH2:35][CH2:36][CH2:37][N:38]4[CH2:41][CH2:42][CH2:43][O:44][CH3:45])=[CH:33][CH:32]=3)=[CH:19][CH:18]=2)[CH2:28][CH2:27]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 69486051HCID 69486051, compound

Product 1

HCID 57249467HCID 57249467, compound

Procedure

In analogy to the procedure described in example 4(b), the (3R,4R)-4-[4-(3-cyclopropylmethoxy-propoxy)-phenyl]-3-[1-(3-methoxy-propyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-piperidine-1-carboxylic acid tert-butyl ester was deprotected with HCl/methanol to yield the (3R,4R)-7-[4-[4-(3-cyclopropylmethoxy-propoxy)-phenyl]-piperidin-3-yloxymethyl]-1-(3-methoxy-propyl)-1,2,3,4-tetrahydro-quinoline as light yellow oil; MS: 523 (M+H)+.

Sources & evidence

ORD record: ord-e05ad5c7da18417f86eb46ca48ca75da
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06197959B1

Reaction notes

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