HCID 21254068, compound → HCID 70226981, compound

Participants

Reaction Steps

A solution of 350 mg (1.43 mmol) of (4-(1-butyl-1H-imidazol-2-ylmethyl)phenyl]hydrazine and 362 mg (1.72 mmol) of 3-chloropropyl 3,5-dimethylphenyl ketone (EXAMPLE 4) in 3 mL of 2-methoxyethanol was stirred at reflux under nitrogen for 3 hours. The solution was then cooled and concentrated in vacuo. Purification of the residue by flash chromatography on silica gel (elution with 95:5 CH2Cl2-MeOH followed by 95:5:0.5 CH2Cl2-MeOH-concd. NH4OH) gave 50 mg (9%) of material that was satisfactory for use in the next step.

Provenance & Evidence