HCID 21254055, compound → HCID 21254077, compound

HRID 1531569Notes

Reaction equation

HRID 1531569 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([NH:12]N)=[CH:8][CH:7]=1.[CH3:14][C:15]1[CH:16]=[C:17]([C:22]2[NH:23][C:24]3[C:29]([C:30]=2CCNCCCCC2C=CC(NS(C)(=O)=O)=CC=2)=CC(C(N2CCOCC2)=O)=CC=3)[CH:18]=[C:19]([CH3:21])[CH:20]=1>>[CH3:14][C:15]1[CH:16]=[C:17]([C:22]2[NH:12][C:9]3[C:10]([C:30]=2[CH2:29][CH2:24][NH2:23])=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)=[CH:7][CH:8]=3)[CH:18]=[C:19]([CH3:21])[CH:20]=1

Participants

3

Reactant 2

HCID 21254055HCID 21254055, compoundHCID 21254068HCID 21254068, compound

Product 1

HCID 21254077HCID 21254077, compoundYield 14%

Procedure

Reaction of (4-thiazol-2-ylphenyl)hydrazine and 3-chloropropyl 3,5-dimethylphenyl ketone (EXAMPLE 4) was carried out according to the procedure of Example 7.1, Step D to give a 14% yield of the title compound as a yellow, stiff foam, mp 98.5°-100.5° C.; homogeneous by TLC in 95:5 CH2Cl2-MeOH. 500 MHz 1H NMR (CDCl3) was consistent with the assigned structure. Mass spectrum (PB-NH3/CI): m/e=348.2 (M+H).

Sources & evidence

ORD record
ord-6e6733ba457d4dfe990dcf36d12cbec2
Source dataset
uspto-grants-2001_03
Patent number
US06197975B1

Reaction notes

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