反应详情

A solution of 80 g of 2,4,6-trimethylphenyl bromoethyl ketone bromomethylketone and 35 g of thiourea in 250 ml of methanol is refluxed for 3 hours. After cooling the reaction mixture, the precipitate is filtered off and washed abundantly with diethyl ether. After concentration of the filtrate to a third of the initial volume, a second bath of crystals is recovered. Yield: 70%. m.p.=138 168° C. The hydrobromide prepared by the action of HBr in ethanol melts at 295° C.

1. temperatureAfter cooling the reaction mixture
2. filtrationthe precipitate is filtered off
3. washwashed abundantly with diethyl ether
4. customAfter concentration of the filtrate to a third of the initial volume, a second bath of crystals is recovered
5. customm.p.=138 168° C
6. customThe hydrobromide prepared by the action of HBr in ethanol melts at 295° C.