Hydrochloric Acid → HCID 21249967, compound

Participants

Reaction Steps

A solution of 21.16 g (105.4 mmol) of 1-(3-chloro-4-methoxyphenyl)-2-hydroxypropane in 106 ml of dry benzene is mixed with 15.93 g (105.4 mmol) of 4-nitrobenzaldehyde and 14.36 g (105.4 mmol) of freshly melted zinc chloride, and dry hydrogen chloride gas is introduced for 3 hours. Then, the mixture is heated to boiling for 30 minutes. Working-up is carried out according to the process that is described in Example 3, Step A. The 6-chloro-3-methyl-7-methoxy-1-(4-nitrophenyl)-isochroman that is obtained is first isolated as an oily crude product, which crystallizes during treatment, however, with 370 ml of hot ethanol: 15.79 g (50%, melting point 118-120° C.

Provenance & Evidence