Sodium Iodide → HCID 135528950, compound

Participants

Reaction Conditions

Reaction Steps

7-Benzoylamino-4-hydroxy-3-(4-methoxy-phenylazo-napthalene-2-sulfonic acid isopropyl ester (Example 15, 49 mg, 0.09 mmol) was suspended in 2-butanone (3 mL) and sodium iodide (57 mg, 0.38 mmol) was added. The reaction mixture was allowed to stir under nitrogen at 60° C. for 24 h. The solvent was removed under a stream of nitrogen, acetone was added and the suspension was filtered to provide the title compound (51 mg, 0.08 mmol, 91%) as a red solid: NMR (DMSO-d6): δ 16.30 (s, 1H), 10.68 (s, 1H), 8.26 (d, J=9 Hz, 1H), 8.19 (m, 1H), 8.01 (m, 3H), 7.83 (d, 4H), 7.10 (d, J=9 Hz, 2H), 3.92 (s, 3H); Analytical BPLC: 99% pure; MS (ES-NEG): [M−H] 476; Anal. Calc. for C27H25N3O6S: C, 57.71, H, 3.63, N, 8.41. Found: C, 52.85, H, 4.44, N, 6.66.

Provenance & Evidence