反应详情

A mixture of 3-ethoxycarbonyl-8-amino-quinoline (9.9 g), 2,2-dimethyl-5-methoxymethylene-1,3-dioxan-4,6-dione (Monatsh. Chem., 98:564-78 (1967))(10.3 g) and ethanol (80 ml) was stirred at reflux for 2 hours. The mixture was cooled and filtered. The solid so obtained was washed with ethanol to give 8-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylideneamino)-3-ethoxycarbonylquinoline in 80% yield, mp 228-231° C.

1. temperatureat reflux for 2 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. customThe solid so obtained
5. washwas washed with ethanol