HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Carbamoyl-4-chloro-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Carboxy-8-nitro-4-oxo-3,4-dihydroquinoline | HCID 21250024 | — |
| Product | 3-Carbamoyl-4-chloro-8-nitroquinoline | HCID 21250101 | 79% |
Reaction Steps
Using an analogous procedure to that described in Example 2, in the section relating to the preparation of starting materials, 3-carboxy-8-nitro-4-oxo-3,4-dihydroquinoline was reacted with thionyl chloride and then concentrated aqueous ammonia. The product so obtained was recrystallised from ethanol to give 3-carbamoyl-4-chloro-8-nitroquinoline in 79% yield, mp 277-279° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06200974B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-ac69562a76d2476cb131af0ed80a4978 |
| Source note | uspto-grants-2001_03 |