Sodium Carbonate → HCID 21250511, compound

HRID 1531746Notes

Reaction equation

HRID 1531746 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:21])=[CH:7][C:8]([O:12][C:13]3[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=3)=[N:9]2)=[CH:4][CH:3]=1.[C:22](=[O:25])([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1.O.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[CH:22]([C:2]1[CH:11]=[CH:10][CH:5]=[CH:4][C:3]=1[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:21])=[CH:7][C:8]([O:12][C:13]3[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=3)=[N:9]2)=[CH:4][CH:3]=1)=[O:25]

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 21250217HCID 21250217, compound

Product 1

HCID 21250511HCID 21250511, compound

Reagents, catalysts & solvents 2

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 22272177Toluene waterSolvent

Procedure

Prepared analogously to Example 27e from 4-[(7-bromo-4-methyl-quinolin-2-yl)oxy]-benzonitrile, 2-formylbenzeneboric acid, sodium carbonate and tetrakis-(triphenylphosphine)-palladium (0) in toluene/water.

Sources & evidence

ORD record
ord-3875c3009e1b4b6ea2626bd06700a596
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

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