Bromine → HCID 178419753, compound

HRID 1531753Notes

Reaction equation

HRID 1531753 reaction equation
[Br:1]Br.[OH:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(Cl)(Cl)(Cl)Cl>[BrH:1].[Br:1][C:7]1[CH:8]=[C:9]([N+:10]([O-:12])=[O:11])[C:4]([OH:3])=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 178526677HCID 178526677, compound

Product 1

HCID 178419753HCID 178419753, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

3.6 ml of bromine are added dropwise to a suspension of 10.0 g (0.071 mol) of 2-hydroxy-3-nitro-pyridine in 25 ml of carbon tetrachloride whilst cooling with ice. The reaction mixture is refluxed for 2 hours. The solvent is distilled off in vacuo, the crystalline product is suction filtered and recrystallised from water.

Workup

  1. temperaturewhilst cooling with ice
  2. temperatureThe reaction mixture is refluxed for 2 hours
  3. distillationThe solvent is distilled off in vacuo
  4. filtrationfiltered
  5. customrecrystallised from water

Sources & evidence

ORD record
ord-132ada9f4c804369a9b934f8cd787efd
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

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