Acetic Acid → HCID 21250330, compound

Participants

Reaction Steps

1.2 g (8.8 mmol) of 2,3-diamino-6-chloro-pyridine are dissolved in 20 ml tetrahydrofuran and, after the addition of 2 ml pyridine at 0° C., mixed with 2 ml of benzyl chloroformate. After heating to ambient temperature the mixture is combined with ice water, adjusted to pH 4 with glacial acetic acid and extracted with ethyl acetate. The combined organic extracts are dried and evaporated down. The residue is chromatographed on silica gel and eluted with petroleum ether/ethyl acetate (9:1 and 1:1).

Provenance & Evidence