Triethylamine → HCID 21193990, compound

Participants

Reaction Steps

A solution of 1.2 g (3.0 mmol) of 2-[4-(N-benzyl-methylamino)-3-nitro-phenyl]-2-methyl-3-hydroxy-1-pyrrolidin-1-yl-propan-1-one in 20 ml of tetrahydrofuran was mixed with 1.3 ml of (9.3 mmol) of triethylamine at room temperature. Subsequently, 0.27 ml (3.5 mmol) of methanesulfonylchloride were dropped to the reaction mixture at 2-5° C. The formed precipitate was filtered after 2 hours at room temperature and the filtrate evaporated down. The raw product was further processed without purification.

Provenance & Evidence