Isopropanol → HCID 18361878, compound

Participants

Reaction Steps

The title-compound was prepared from 6-bromo-2-[(tetrahydropyran-2-yl)oxymethyl]pyridine prepared following the procedure given for Example 11 part a and isopropyl alcohol following the procedure given for Example 11 part b, 1H NMR (250 MHz, CDCl3), δ 1.32 (6H, d, J=6.2 Hz, 2 of CH3), 1.6-1.9 (6H, Me, 3 of CH2), 3.56 (1H, m, CH2O), 3.91 (1H, m, CH2O), 4.53 (1H, d, J=13.7 Hz, CH2O), 4.76 (1H, d, J=13.6 Hz, CH2O), 4.79 (1H, m, CHO), 5.29 (1H, septet, J=6.2 Hz, CH), 6.55 (1H, d, J=8.2 Hz, Ar—H), 6.96 (1H, d, J=7.3 Hz, Ar—H), 7.53 (1H, dd, J=8.2 and 7.3 Hz, Ar—H); MS (ES30) m/e 252 [MH]+.

Provenance & Evidence