(1-Methyl-1H-1,2,4-triazol-3-yl)methanol → HCID 21250140, compound

HRID 1531790Notes

Reaction equation

HRID 1531790 reaction equation
[CH3:1][O:2][C:3]1[O:7][N:6]=[C:5]([C:8]2[N:12]3[N:13]=[C:14]([O:21]S(C4C=CC(C)=CC=4)(=O)=O)[C:15]4[C:20]([C:11]3=[N:10][N:9]=2)=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:4]=1.O[CH2:33][C:34]1[N:38]=[CH:37][N:36]([CH3:39])[N:35]=1>>[CH3:1][O:2][C:3]1[O:7][N:6]=[C:5]([C:8]2[N:12]3[N:13]=[C:14]([O:21][CH2:33][C:34]4[N:38]=[CH:37][N:36]([CH3:39])[N:35]=4)[C:15]4[C:20]([C:11]3=[N:10][N:9]=2)=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:4]=1

Participants

3

Reactant 2

HCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanolHCID 18361786HCID 18361786, compound

Product 1

HCID 21250140HCID 21250140, compound

Procedure

The title-compound was prepared from 3-(5-methoxyisoxazol-3-yl)-6-(4-toluenesulphonyloxy)-1,2,4-triazolo[3,4-a]phthalazine (prepared as described in Example 118 part a) and 3-hydroxymethyl-1-methyl-1,2,4-triazole (prepared using the conditions of Itoh and Okongi, EP-A-421210) using the conditions given for in Example 98, 1H NMR (360 MHz, CDCl3) δ 3.96 (3H, s, CH3), 4.15 (3H, s, CH3), 5.72 (2H, s, CH2), 6.30 (1H, s, Ar—H), 7.79 (1H, m, Ar—H), 7.95 (1H, m, Ar—H), 8.07 (1H, s, Ar—H), 8.28 (1H, d, J=8.4 Hz, Ar—H), 8.68 (1H, d, J=8.4 Hz, Ar—H); MS (ES30) m/e 379 [MH]+; Anal. Found. C, 53.97; H, 3.73; N, 29.62. C17H14N8O3 requires C, 54.04; H, 3.48; N, 29.32%.

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-01f9665f0b40451e985830f97b2009df
Source dataset
uspto-grants-2001_03
Patent number
US06200975B1

Reaction notes

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