(1-methyl-1H-1,2,4-triazol-5-yl)methanol → 3-(3-Methylisoxazol-5-yl)-6-(2-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

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Reaction Steps

The title-compound was prepared from the product of Example 120 part a and 2-methyl-1,2,4-triazole-3-methanol (prepared using the conditions of Itoh and Okongi, EP-A-42120) following the procedure given for Example 98, 1H NMR (400 MHz, CDCl3) δ 2.43 (3H, s, CH3), 4.16 (3H, s, CH3), 5.82 (2H, s, CH2), 7.07 (1H, s, Ar—H), 7.84 (1H, m, Ar—H), 7.95-8.04 (2H, m, 2 of Ar—H), 8.21 (1H, d, J=8.0 Hz, Ar—H), 8.62 (1H, d, J=8.0 Hz, Ar—H); MS(ES30) m/e 363 [MH]+; Anal. Found. C, 56.12; H, 3.90; N, 30.74. C17H14N8O2 requires C, 56.35; H, 3.89; N, 30.92%.

Provenance & Evidence