(1-Methyl-1H-1,2,4-triazol-3-yl)methanol → 3-(3-Methylisoxazol-5-yl)-6-(1-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Participants

Role	Name	HCID	Charge
Reactant	(1-Methyl-1H-1,2,4-triazol-3-yl)methanol	HCID 10351670	—
Reactant	3-(3-Methylisoxazol-5-yl)-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine	HCID 18361890	—
Product	3-(3-Methylisoxazol-5-yl)-6-(1-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine	HCID 18361882	—

Reaction Steps

The title-compound was prepared from the product of Example 120 part a and 3-hydroxymethyl-1-methyl-1,2,4-triazole (prepared using the conditions of Itoh and Okongi, EP-A-421210) following the conditions described for Example 71, mp 270-271.5° C.; 1H NMR (360 MHz, CDCl3) δ 2.50 (3H, s, CH3), 3.97 (3H, s, CH3), 5.73 (2H, s, CH2), 7.31 (1H, s, Ar—H), 7.82 (1H, m, Ar—H), 7.97 (1H, m, Ar—H), 8.09 (1H, s, Ar—H), 8.31 (1H, d, J=8.6 Hz, Ar—H), 8.70 (1H, d, J=8.6 Hz, Ar—H); MS (ES30) m/e 363 [MH]+; Anal. Found. C, 55.92; H, 3.63; N, 30.16. C17H14N8O2.0.06CH2Cl2 requires C, 55.77; H, 3.87, N, 30.49%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06200975B1
Source dataset	uspto-grants-2001_03
ORD ID	ord-e0d25c01136e46b3bbacb98f441b771b
Source note	uspto-grants-2001_03