Ethyl Bromide → HCID 21250523, compound

Participants

Reaction Conditions

Reaction Steps

2 Ethylcarboxy-5-cyanoindole (497 mg) [Liebigs Ann Chem, (3), 438-55 (1986)] and potassium carbonate (960 mg) were mixed in acetonitrile (25 ml) and bromoethane (191 μl) added. The reaction mixture was stirred for 18 hrs at 80° C. under a atmosphere of nitrogen. Iodoethane (200 μl) was added and the reaction mixture heated to 60° C. for 18 hrs after which time the mixture was diluted with ethyl acetate (100 ml) and washed with water, dried over MgSO4 and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel eluting with Hexane/Isopropanol/ 0.88 ammonium hydroxide (95/5/0.25, v/v) to afford the title compound as a white solid (455 mg).

Provenance & Evidence