Water → HCID 54204989, compound

Participants

Reaction Steps

A mixture of 3-(4-aminopiperidin-1-yl)-1-chloropropane (1g; preparation 9), sodium carbonate (0.42 g) and toluoyl chloride (0.58 ml) in 20 ml of ethyl acetate and 20 ml of saturated aqueous sodium bicarbonate solution was stirred at room temperature for 3 hour, then poured into 100 ml of water. The organic phase was separated, dried over sodium sulfate and concentrated to dryness. The residue (1.4 g) was crystallized from 20 ml of hexane and the collected solid dried under vacuum at 50° C. to give 1.05 g of the product, m.p. 150-152° C.

Provenance & Evidence