Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | HCID 13226134 | HCID 13226134 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21251008 | HCID 21251008 | 33% |
Reaction Steps
A mixture of 1.94 g (0.01 mol) of 2-aminocyclohexanone hydrobromide, 1.19 g (0.01 mol) of phenyl isocyanate and 4 ml of pyridine is stirred at 125° C. for 4 hours. Water is added, the mixture is stirred until crystallization is obtained, drained, washed with water and dried. The compound is purified by flash chromatography on silica, eluting with a 95:5 CH2Cl2/CH3OH mixture. 0.7 g of product is recovered. Yield=33% (m.p.=224° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06200991B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-7cf38e221ee04d988d482fe0a98642ee |
|---|
| Source note | uspto-grants-2001_03 |
|---|
