Water → 5-Bromo-2,4-bis(1,1-dimethylethoxy)pyrimidine

Participants

Reaction Steps

To a solution of potassium tert-butoxide (67.5 g) in tetrahydrofuran (500 ml) was added dropwise a solution of 5-bromo-2,4-dichloropyrimidine (55 g) (J.Am.Chem.Soc. 1934, 56, 134) in tetrahydrofuran (100 ml). After 1.5 hours, water (100 ml) was added carefully and the mixture extracted with ethyl acetate. The combined extract was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromtography eluting with isohexane. Yield 52.4 g.

Provenance & Evidence